Alla Anatolievna Nakonechna

Degree: M.D., Ph.D.
Date of birth: August 22, 1964
Birthplace: Voznesensk, Nikolaewskaja reg., Ukraine
Marital status: married
Nationality: Dutch and Ukrainian

Home Address: 3 Brook Hey
Parkgate
Neston
CH64 6TH
United Kingdom

Telephone: +44 151 3365256 (home) +44 7717 834235 (mobile)
E-mail: alla.nakonechna@novidec.com

unlimited right to live and work in United Kingdom and/or European Union
Full Registration (licence to practise, ref number 6133469) as doctor granted by GMC (General Medical Council)

Professional experience and education history:

Employment history

Awards and honours:

1. Ph.D degree - from National Medical University - May, 2002 The subject of my dissertation scientific work "Clinical-immunological mechanisms of enterosorbtion in the complex treatment of chronic hepatitis."
2. Expert of DAAD Foundation in Ukraine (Kiev) - Member of the Expert Committee for the selection of the Projects in the field of Medicine - from 2004
3. Honorary Professor at National Institution of Paediatrics Obstetrics and Gynaecology of National Academy of Medical Science of Ukraine
4. Award of National Academy of Science of Ukraine 1918-2018 - Medal "People's Recognition for Ukrainian Scientist 1918-2018" - 27.02.2020
5. International Member of the Academic Council at National Academy of Medical Science of Ukraine

Membership in Professional and Scientific Societies

• From 1995- Member of Ukrainian Society of Clinical Immunology and Allergology
• From 1996- Member of Russian Association of Allergology and Clinical Immunology
• From 1996- Member of EAACI - European Academy of Allergology and Clinical Immunology
  • Active member of the Drug Allergy Interest Group
  • ENDA Group- European Network in Drug Allergy - Active Member
  • ARIA Group- Allergic Rhinitis and Impact on Asthma - Active Member
• From 1997- Member of ESPEN - European Society of Parenteral and Enteral Nutrition
• From 1998- Member of AAAAI - American Academy of Allergology, Astma and Immunology
  • AAAAI Anaphylaxis Committee - Active Member
  • AAAAI Adverse Reactions to Drugs, Biologicals and Latex Committee - Active Member
• From 1999- Member of ACAAI - American College of Allergology, Astma and Immunology
• From 2005- Member of BSACI - British Society of Allergology and Clinical Immunology
• From 2009- Member of ERS - European Respiratory Society

Grants and Fellowships:

• 1.04 - 1.08.2001 - Tel Aviv University, Sackler Faculty of Medicine, Israel International Postgraduate Training Program in Medicine
• 1.04 - 1.08.2003 - DAAD Fellowship at Philipps University, Marburg, Germany
• From 1996 till 2010 – received EAACI Grants for attending Annual EAACI Congresses with oral or poster presentations.
• From 1998 till 2007 – received AAAAI Grants for attending Annual AAAAI Congresses with oral or poster presentations.
• 18 June - 5 July 2004 - Nancy University Hospital, Nancy, France
• October 2004 - International Consensus Meeting on Urticaria in Berlin
• May 2005 - grant from American Austrian Foundation for course "Infectious Diseases" in Salzburg
• April 2006 - Food Allergy Training Course in Middelfart, Denmark
• December 2007 - BSACI travel grant to visit WAO congress Bangkok
• 14 January - 31 January 2008 - Vienna University Hospital (Dermatology, Immunology and Allergy dept.), Vienna, Austria
• July 2009 - EAACI travel grant to attend Summer Allergy School – Norwich
• September 2009 - Asthma UK travel grant to attend ERS congress Vienna

Research topics

• The role of the immune system in the inflammation process and in allergic and autoimmune diseases;
  • Inflammatory cells (macrophages, Tcells, B-cells, eosinophils. neutrophils) and mediators (cytokine and chemokines) in the immune response,
  • Mechanisms of apoptosis. The role of interactions between dendritic cells (DC) and T-lymphocytes in the maintenance and destroyment of the mechanisms of apoptosis and tolerance (oral and systemic) in allergic disease in children and adults.
• Drug allergy: drug hypersensitivity reactions (type I-IV)
  • immune mechanism, diagnostic tests, treatment.
  • genetics in drug hypersensitivity reaction (immediate and delayed type).
  • desensitisation mechanisms in drug hypersensitivitity reactions.
  • Epidemiology in drug hypersensitivity reactions (type I-IV) in children and adults
  • Evaluation of drug safety.
• Allergic rhinoconjunctivitis and asthma in adult and children: immune mechanisms, diagnostic criteria, phenotypes and treatment.
• Specific immunotherapy (SIT) - subcutaneous (SCIT) and sublingual (SLIT) in treatment of allergic diseases in adult and children.
• Anaphylaxis - immune mechanisms, diagnostic, treatment.
  • Food and drug anaphylaxis: mechanisms, diagnostic tests, treatments.
  • Idiopathic anaphylaxis.
  • Anaphylaxis in children and pregnant.
• Food allergy in adult and children: immune mechanisms, diagnostic, treatment.
  • mechanisms, management and treatment.
  • Eosinophilic esophagitis in adults: mechanisms, management and treatment.
• Chronic urticaria and angioedema: mechanisms, management and treatment
• The gut microflora and food allergy.
• Mucosal immunity: immuno - epithelial interactions in the mucosal tissue.
  • The role of mucosal immunity in maintenance and disturbance of oral and systemic tolerance and in the development allergic disease.
• The peculiarity of the immune responce to the infection (especially viral infectionand infections of the gastrointestinal tract). The role of infection in allergic, autoimmune, oncological diseases and new ways of their treatment.
• Pharmacotherapy of allergic and autoimmune diseases.
• Nutrition and allergy. The role of nutrition in the prevention of allergy (especially food allergy) as well in childhood as in adults.
• The role of pre- and probiotics in the treatment and prevention of allergic diseases: asthma and atopic dermatitis.

Professional Activities

during the work in National Medical University, Kiev, Ukraine

• Teaching course of Clinical Immunology and Allergology at National Medical University, Kiev, Ukraine.
• Responsible for methodical, research and clinical work (observing and treating patients with immune desorders and allergical pathology) at the Department of Clinical Immunology and Allergology.

during the work in Manchester Royal Infirmary (MRI) as a Clinical Research Fellow

• Investigate patients with Allergic diseases (Allergic rhinoconjunctivitis, Asthma, Atopic dermatitis and Eczema, Food and Drug allergy, Anaphylaxis)
• Provide the selection of patients according to Clinical Trial Protocol
• Performing medical procedures - Skin Prick Tests (SPT) with set of different allergens groups; Lung functions; blood samples for immunological analysis
• Select patients for Double-blind Placebo Control Food Challenge (according to Inclusion and Exclusion criteria’s of Clinical Trial Protocol
• Create a database
• Recruit patients in Clinical Trial
• Responsible for all trial related medical decisions
• Filling in the Case Report Forms (CRF) and Questionaires
• Create documents for Ethic Committee

during the work in Royal Liverpool and Broadgreen University Hospitals as Consultant Allergist:

• Investigate patients with Allergic diseases (Allergic rhinoconjunctivitis, Asthma, Atopic dermatitis and Eczema, Food and Drug allergy, Anaphylaxis, Chronic urticaria and angioedema)
  • Performing medical procedures - Skin Prick Tests (SPT) with set of different allergens groups; Lung functions; blood samples for immunological analysis; challenge tests (oral, intradermal, subsutaneous)
  • Select and Recruit patients in Clinical Trials
• for Multicentre, Multinational study - Chronic urticaria and angioedema
  • Create a database of Multicentre, Multinational study
  • Responsible for all trial related medical decisions
  • Filling in the Case Report Forms (CRF) and Questionaires
  • Create documents for Ethic Committee
• Participate in preparing publications and presentations of the Studies' results
• Provide Educational Session for Junior Doctors, GPs and other specialities Doctors
• Provide Audits in Allergy Clinic - in Anaphylaxis, WDEIA (wheat dependant excercise induced anaphylaxis), Drug hypersensitivity reactions, SIT (specific immunotherapy)
• Create join/parallel clinics with ENT, Respiratory and Dermatology Clinics
• Participate in International Congresses and Conferences to present the results of studies and exchange skills and knowledge in Allergy and Clinical Immunology

Publications and patents:

67 publications in different International Journals and 2 patents

Interests:

History and culture of the different countries, theatres, museums, music, travelling, swimming, hiking.
New diagnostical methods and treatment of allergic and autoimmune disease.

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